Goulmy E, Persijn G, Blokland E, D'Amaro J, van Rood J J
Transplantation. 1981 Mar;31(3):210-7. doi: 10.1097/00007890-198103000-00014.
Cell-mediated lympholysis (CML) reactivity against the splenocytes of the kidney donor might be a good in vitro correlate of the homograft reaction. The present study was performed in an attempt to determine whether CML nonreactivity between unrelated donor-recipient combinations occur and, if so, under what conditions. We were able to show that CML nonreactivity occurs between unrelated donor-recipient combinations in 70% of the nonrejecting patients, whereas all of the rejecting patients were CML reactive. Patients with CML nonreactivity did clinically well more frequently than those that were CML reactive. The question as to whether or not such variables as HLA-A, B, and DR match and sex, the number of pretransplant blood transfusions, and the degree of presensitization, etc. predispose to the development of donor-specific CML nonreactivity was studied as well. Sex and compatibility for HLA-B antigens between donor and recipient might be such factors.
针对肾脏供体脾细胞的细胞介导淋巴细胞溶解（CML）反应性可能是同种异体移植反应良好的体外相关指标。本研究旨在确定在不相关供体 - 受体组合中是否会出现CML无反应性，如果出现，是在什么条件下。我们能够证明，在70%的未发生排斥反应的患者中，不相关供体 - 受体组合之间存在CML无反应性，而所有发生排斥反应的患者CML均呈反应性。CML无反应性的患者在临床上比CML呈反应性的患者更常表现良好。我们还研究了诸如HLA - A、B和DR配型、性别、移植前输血次数以及致敏程度等变量是否会导致供体特异性CML无反应性的发生。供体与受体之间的性别以及HLA - B抗原相容性可能是此类因素。
