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“非致病性”奈瑟菌具有致病性吗?

Are the "nonpathogenic" Neisseriae pathogenic?

作者信息

Herbert D A, Ruskin J

出版信息

Am J Clin Pathol. 1981 May;75(5):739-43. doi: 10.1093/ajcp/75.5.739.

DOI:10.1093/ajcp/75.5.739
PMID:7015824
Abstract

Neisseriae other than N. meningitidis and N. gonorrhoeae are common upper respiratory commensals, but rarely cause disease. A case of N. sicca bacteremia in an immunocompromised patient is reported, and the literature dealing with infections attributed to these usually nonpathogenic organisms is reviewed. These neisseriae have been shown to cause meningitis, endocarditis, sepsis, and some cases of pneumonia, otitis media, and sinusitis; however, their pathogenicity is doubtful in many of the reported cases of urethritis, cervicitis, and upper respiratory infection. They are not uniformly sensitive to the penicillins, so therapy should be guided by the results of antimicrobial susceptibility testing.

摘要

除脑膜炎奈瑟菌和淋病奈瑟菌外的其他奈瑟菌是常见的上呼吸道共生菌,但很少引起疾病。本文报告了1例免疫功能低下患者发生干燥奈瑟菌血症的病例,并对有关这些通常无致病性的微生物所致感染的文献进行了综述。这些奈瑟菌已被证实可引起脑膜炎、心内膜炎、败血症以及一些肺炎、中耳炎和鼻窦炎病例;然而,在许多报告的尿道炎、宫颈炎和上呼吸道感染病例中,它们的致病性存疑。它们对青霉素并非均一敏感,因此治疗应根据抗菌药物敏感性试验结果来指导。

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1
Are the "nonpathogenic" Neisseriae pathogenic?“非致病性”奈瑟菌具有致病性吗?
Am J Clin Pathol. 1981 May;75(5):739-43. doi: 10.1093/ajcp/75.5.739.
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The nonpathogenic commensal Neisseria: friends and foes in infectious disease.无致病性共生奈瑟菌:传染病中的朋友和敌人。
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Native-valve endocarditis due to Neisseria sicca: case report and review.干燥奈瑟菌所致自体瓣膜心内膜炎:病例报告及文献复习
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The pathogenic potential of commensal species of Neisseria.奈瑟菌共生菌的致病潜力。
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Endocarditis due to Neisseria sicca: report of one case.干燥奈瑟菌引起的心内膜炎:1例报告。
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[Pathogenic neisseriae--model of bacterial virulence and genetic flexibility].[致病性奈瑟菌——细菌毒力与遗传灵活性模型]
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The significance of nongonococcal, nonmeningococcal Neisseria isolates from blood cultures.血培养中分离出的非淋球菌、非脑膜炎球菌奈瑟菌的意义。
Rev Infect Dis. 1984 Mar-Apr;6(2):181-8. doi: 10.1093/clinids/6.2.181.
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Identification and characterization of specific sequences encoding pathogenicity associated proteins in the genome of commensal Neisseria species.共生奈瑟菌属物种基因组中编码致病性相关蛋白的特定序列的鉴定与表征
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Infection and Branhamella catarrhalis.感染与卡他布兰汉菌。
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引用本文的文献

1
Atypical, Yet Not Infrequent, Infections with Species.由该物种引起的非典型但并非罕见的感染。
Pathogens. 2019 Dec 20;9(1):10. doi: 10.3390/pathogens9010010.
2
Biochemical and genomic analysis of the denitrification pathway within the genus Neisseria.对奈瑟氏菌属中反硝化途径的生化和基因组分析。
Microbiology (Reading). 2009 Dec;155(Pt 12):4093-4103. doi: 10.1099/mic.0.032961-0. Epub 2009 Sep 17.
3
A population-based study of hospital admission incidence rate and bacterial aetiology of acute lower respiratory infections in children aged less than five years in Bangladesh.
一项关于孟加拉国五岁以下儿童急性下呼吸道感染的住院发病率和细菌病因的基于人群的研究。
J Health Popul Nutr. 2007 Jun;25(2):179-88.
4
Asymptomatic Neisseria subflava biovar perflava bacteriuria in a child with obstructive uropathy.
Eur J Clin Microbiol Infect Dis. 1993 Jul;12(7):540-5. doi: 10.1007/BF01970960.
5
Neisseria sicca peritonitis in a patient maintained on chronic peritoneal dialysis.一名接受慢性腹膜透析治疗的患者发生干燥奈瑟菌腹膜炎。
Pediatr Nephrol. 1994 Oct;8(5):601-2. doi: 10.1007/BF00858142.
6
Neisseria sicca osteomyelitis.干燥奈瑟菌骨髓炎
J Clin Microbiol. 1982 Sep;16(3):595-7. doi: 10.1128/jcm.16.3.595-597.1982.
7
Branhamella catarrhalis conjunctivitis.卡他布兰汉菌性结膜炎
Can Med Assoc J. 1983 Apr 15;128(8):955-6.
8
Neisseria lactamica septicemia in an immunocompromised patient.免疫功能低下患者的乳酸奈瑟菌败血症
J Clin Microbiol. 1983 May;17(5):934-5. doi: 10.1128/jcm.17.5.934-935.1983.
9
Distribution of an antigenically related iron-regulated protein among the Neisseria spp.一种抗原相关的铁调节蛋白在奈瑟菌属中的分布
Infect Immun. 1986 Jan;51(1):60-8. doi: 10.1128/iai.51.1.60-68.1986.
10
Pulmonary cavitation due to Neisseria mucosa in a child with chronic neutropenia.一名慢性中性粒细胞减少症患儿因黏液奈瑟菌导致肺空洞形成。
Eur J Clin Microbiol Infect Dis. 1988 Apr;7(2):175-6. doi: 10.1007/BF01963073.