McMillan C W
Am J Pediatr Hematol Oncol. 1981 Spring;3(1):97-103.
Most of our current knowledge about the roles of blood vessels, platelets, and plasma factors in hemostasis has been gained in the last three decades. However, prior to this period a relatively limited but critical framework of ideas about hemostasis had slowly but steadily evolved, beginning in 1666 when Malpighi discovered fibrin in blood clots. By the turn of the 20th century aggregation of platelets at the site of blood vessel injury was recognized and four enduring coagulation factors emerged: fibrinogen, prothrombin, tissue extracts (thromboplastin), and calcium. Them progress exploded after World War II, leading us into a search for the molecular basis of hemostasis where we are today. Through it all, observations made at the bedside by astute clinicians have been a driving force in the advancement of basic knowledge.
在过去三十年里，我们获得了关于血管、血小板和血浆因子在止血过程中作用的大部分现有知识。然而，在此之前，从1666年马尔皮基在血凝块中发现纤维蛋白开始，一个关于止血的相对有限但至关重要的思想框架已经缓慢而稳步地发展起来。到20世纪之交，人们认识到血小板在血管损伤部位的聚集，并且出现了四种持久的凝血因子：纤维蛋白原、凝血酶原、组织提取物（凝血活酶）和钙。第二次世界大战后进展突飞猛进，引领我们进入了对止血分子基础的探索，即我们如今所处的阶段。在这一过程中，敏锐的临床医生在床边所做的观察一直是基础知识进步的驱动力。
