Nathan D M, Axelrod L, Flier J S, Carr D B
Ann Intern Med. 1981 May;94(5):653-6. doi: 10.7326/0003-4819-94-5-653.
Three patients with antibody-mediated insulin resistance were treated with U-500 regular insulin subcutaneously. Insulin requirements decreased dramatically (55% to 75%) when therapy was changed from U-100 NPH pork to equivalent doses of U-500 regular pork insulin. There was no difference in antibody affinity for the insulin in these two preparations as shown by competition experiments. These observations demonstrate that U-500 insulin is a useful alternative in the treatment of antibody-mediated insulin resistance. The mechanism for this effect is yet to be determined.
三名抗体介导的胰岛素抵抗患者接受了皮下注射U - 500常规胰岛素治疗。当治疗从U - 100中性精蛋白锌胰岛素改为等效剂量的U - 500常规猪胰岛素时，胰岛素需求量显著下降（55%至75%）。竞争实验表明，这两种制剂中的胰岛素抗体亲和力没有差异。这些观察结果表明，U - 500胰岛素是治疗抗体介导的胰岛素抵抗的一种有用替代药物。这种效应的机制尚待确定。
