Kłosiewicz-Latoszek L, Naruszewicz M, Cybulska B, Szostak W B, Chotkowska E
Acta Physiol Pol. 1982 Jan-Apr;33(1-2):47-56.
The purpose of the study was an assessment of the lipid and protein composition of very low density lipoproteins (VLDL) in hyperlipoproteinaemias type IIa, IIb, III and IV. Besides that, cholesterol was determined in low density lipoproteins (LDL) and high density lipoproteins (HDL). Fifty-seven patients with idiopathic hyperlipoproteinaemia and nineteen subjects without lipid metabolism disturbances were studied. The VLDL fraction was obtained by ultracentrifugation of the serum. The LDL and HDL fractions were separated by precipitation. A raised value of the LDL:HDL cholesterol ratio was found in hyperlipoproteinaemias type IIb, III and IV. Positive correlations between the concentrations of lipid and protein components of the VLDL fraction were found in hyperlipoproteinaemias type IIa, IIb, IV and in normolipaemia, which suggests maintained proportions between VLDL components. The high proportion of cholesterol in the VLDL fraction in relation to other components in type III hyperlipoproteinaemia indicates an abnormal composition of this fraction.
该研究的目的是评估IIa型、IIb型、III型和IV型高脂蛋白血症中极低密度脂蛋白（VLDL）的脂质和蛋白质组成。除此之外，还测定了低密度脂蛋白（LDL）和高密度脂蛋白（HDL）中的胆固醇。对57例特发性高脂蛋白血症患者和19例无脂质代谢紊乱的受试者进行了研究。通过血清超速离心获得VLDL组分。通过沉淀分离LDL和HDL组分。在IIb型、III型和IV型高脂蛋白血症中发现LDL:HDL胆固醇比值升高。在IIa型、IIb型、IV型高脂蛋白血症和正常血脂血症中，VLDL组分的脂质和蛋白质成分浓度之间存在正相关，这表明VLDL各组分之间的比例保持不变。III型高脂蛋白血症中VLDL组分中胆固醇相对于其他成分的比例较高，表明该组分的组成异常。
