Stringer M D, Görög P G, Freeman A, Kakkar V V
Thrombosis Research Unit, King's College Hospital, London.
BMJ. 1989 Feb 4;298(6669):281-4. doi: 10.1136/bmj.298.6669.281.
Plasma lipid peroxide concentrations were measured in 100 patients with occlusive arterial disease proved angiographically (50 patients with ischaemic heart disease, 50 with peripheral arterial disease) and compared with values in 75 control patients with no clinical evidence of atherosclerosis. Lipid peroxide concentrations were significantly higher in patients both with ischaemic heart disease (median 4.37 mumol/l (interquartile range 3.85-5.75 mumol/l); p less than 0.001) and with peripheral arterial disease (median 4.37 mumol/l (3.88-5.21 mumol/l); p less than 0.001) than in controls (median 3.65 mumol/l (interquartile range 3.29-3.89 mumol/l). Overall there was a significant but weak correlation between plasma lipid peroxide and plasma triglyceride concentrations (rs = 0.25; p less than 0.001) but not between plasma lipid peroxide and plasma total cholesterol concentrations. Furthermore, hypertension, obesity, diabetes, smoking, positive family history, and intake of beta blockers and thiazide diuretics were not associated with significant differences in lipid peroxide values. This study provides clinical support to experimental data indicating that peroxidised lipids may be important in atherogenesis and its complications and also suggests that peroxidised lipids may provide an index of the severity of atherosclerosis.
对100例经血管造影证实患有闭塞性动脉疾病的患者（50例缺血性心脏病患者，50例外周动脉疾病患者）测定了血浆脂质过氧化物浓度，并与75例无动脉粥样硬化临床证据的对照患者的值进行比较。缺血性心脏病患者（中位数4.37μmol/l（四分位间距3.85 - 5.75μmol/l）；p<0.001）和外周动脉疾病患者（中位数4.37μmol/l（3.88 - 5.21μmol/l）；p<0.001）的脂质过氧化物浓度均显著高于对照组（中位数3.65μmol/l（四分位间距3.29 - 3.89μmol/l））。总体而言，血浆脂质过氧化物与血浆甘油三酯浓度之间存在显著但较弱的相关性（rs = 0.25；p<0.001），而血浆脂质过氧化物与血浆总胆固醇浓度之间无相关性。此外，高血压、肥胖、糖尿病、吸烟、阳性家族史以及β受体阻滞剂和噻嗪类利尿剂的使用与脂质过氧化物值的显著差异无关。本研究为实验数据提供了临床支持，表明过氧化脂质在动脉粥样硬化及其并发症中可能起重要作用，并且还表明过氧化脂质可能提供动脉粥样硬化严重程度的指标。
