Lima J P
Arq Gastroenterol. 1980 Jul-Sep;17(3):149-60.
Bile secretion by the liver is thoroughly reviewed on its histologic and functional aspects. Regarding biliary flux, it is quantified as dependent or independent from bile acids. The mechanisms of excretion of other compounds like organic anions, cholesterol and phospholipids, are described. Such aspects allow the classification of intrahepatic cholestasis, based on their mechanisms, which can encompass the following: 1) decreased bile acid synthesis; 2) qualitative changes of bile acids; 3) enzymatic changes of the canalicular membrane; 4) changes in the permeability of the canalicular membrane; 5) dysfunction of the contractile microfilaments of the hepatocyte.
本文从组织学和功能方面对肝脏胆汁分泌进行了全面综述。关于胆汁流量，可根据其是否依赖胆汁酸进行量化。文中描述了有机阴离子、胆固醇和磷脂等其他化合物的排泄机制。基于这些机制，可对肝内胆汁淤积进行分类，包括：1）胆汁酸合成减少；2）胆汁酸性质改变；3）胆小管膜酶变化；4）胆小管膜通透性改变；5）肝细胞收缩微丝功能障碍。
