Margolese R G
Can J Surg. 1981 May;24(3):293-4, 299.
After several decades in which the scope and intensity of regional therapies increased, without a corresponding increase in cure rates, attention has turned to systemic treatments. Adjuvant therapy for carcinoma is use in an attempt to destroy micrometastases thus preventing the development of clinical metastases. Initial results have been encouraging and an understanding of tumor cell kinetics has led to the use of better schedules and combinations of drugs that have substantially decreased the probability or treatment failure and prolonged survival compared with the results of operation alone.
在区域治疗的范围和强度增加了几十年而治愈率却没有相应提高之后，人们的注意力已转向全身治疗。癌的辅助治疗用于试图摧毁微转移灶，从而防止临床转移的发生。初步结果令人鼓舞，对肿瘤细胞动力学的了解已导致使用更好的给药方案和药物组合，与单纯手术的结果相比，这些方案和组合已大幅降低了治疗失败的概率并延长了生存期。
