Jindal S P, Lutz T, Hallstrom C, Vestergaard P
Clin Chim Acta. 1981 May;112(3):267-73. doi: 10.1016/0009-8981(81)90449-6.
A quantitative gas chromatographic-mass spectrometric (GC-MS) assay was developed for the determination of benztropine in human urine and plasma. The assay utilizes selected ion focusing to monitor in a GC effluent a specific fragment ion of benztropine generated by electron-impact ionization. Benztropine-d3 was the internal standard. The assay can measure 5 ng/ml of benztropine/ml with about 6% precision. The curve relating the amounts of benztropine added versus the amounts found over a large range of benztropine concentrations was a straight line with a nearly zero intercept and a slope of 0.98 +/- 0.02. The method was used for the analysis of benztropine in urine and plasma of patients on therapeutic dose of the drug.
已开发出一种定量气相色谱 - 质谱（GC - MS）分析法，用于测定人尿液和血浆中的苯海索。该分析法利用选择离子聚焦来监测气相色谱流出物中由电子轰击电离产生的苯海索特定碎片离子。苯海索 - d3为内标。该分析法能够以约6%的精密度测量每毫升5纳克/毫升的苯海索。在很大范围的苯海索浓度下，添加的苯海索量与测得的量之间的曲线是一条截距近零、斜率为0.98±0.02的直线。该方法用于分析接受该药物治疗剂量的患者尿液和血浆中的苯海索。
