Kirkland J L, Barrett G N, Stancel G M
Endocrinology. 1981 Jul;109(1):316-8. doi: 10.1210/endo-109-1-316.
The uterine growth response to estradiol as determined by luminal epithelial cell division was measured in euglycemic and drug induced insulin deficient rats. The results demonstrated that uterine cell division in insulin deficient rats is depressed when compared to euglycemic rats. Replacement of insulin by osmotic minipumps (Alza Corporation) in insulin deficient rats restored the level of luminal cell division to those observed in euglycemic rats.
通过腔上皮细胞分裂测定了正常血糖和药物诱导的胰岛素缺乏大鼠子宫对雌二醇的生长反应。结果表明，与正常血糖大鼠相比，胰岛素缺乏大鼠的子宫细胞分裂受到抑制。通过渗透微型泵（阿尔扎公司）给胰岛素缺乏大鼠补充胰岛素，可使腔上皮细胞分裂水平恢复到正常血糖大鼠所观察到的水平。
