Nakamura Y, Yoshida T, Osumi T, Araki Y, Kondo M
Endocrinol Jpn. 1980 Oct;27(5):585-91. doi: 10.1507/endocrj1954.27.585.
The effect of Bordetella pertussis vaccine on plasma glucose, insulin and glucagon secretion was investigated in normal and alloxan dogs. On the 8th day after the vaccine injection, in normal and alloxan dogs during the infusion of arginine and glucose, the plasma glucose level was lower and the IRI level was higher than in the saline controls. On the other hand, the plasma IRG level showed no significant alloxan dogs this vaccine made the plasma IRG level lower during arginine infusion than in the saline controls and suppressed it significantly during glucose infusion. These effects of the vaccine disappeared on the 30th day after its injection into normal and alloxan dogs. It is suggested that in normal dogs Bordetella pertussis vaccine decreased plasma glucose through the promotion of insulin secretion without any effect on glucagon secretion, while in alloxan dogs this vaccine might alleviate hyperglycemia through the enhancement of insulin and the inhibition of glucagon secretion.
在正常犬和四氧嘧啶糖尿病犬中研究了百日咳博德特氏菌疫苗对血浆葡萄糖、胰岛素和胰高血糖素分泌的影响。在疫苗注射后的第8天，在正常犬和四氧嘧啶糖尿病犬输注精氨酸和葡萄糖期间，血浆葡萄糖水平较低，胰岛素免疫反应性（IRI）水平高于生理盐水对照组。另一方面，血浆胰高血糖素免疫反应性（IRG）水平在四氧嘧啶糖尿病犬中，该疫苗使精氨酸输注期间的血浆IRG水平低于生理盐水对照组，并在葡萄糖输注期间显著抑制其水平。在正常犬和四氧嘧啶糖尿病犬中注射疫苗后的第30天，这些疫苗的作用消失。提示在正常犬中，百日咳博德特氏菌疫苗通过促进胰岛素分泌降低血浆葡萄糖，而对胰高血糖素分泌无影响，而在四氧嘧啶糖尿病犬中，该疫苗可能通过增强胰岛素和抑制胰高血糖素分泌来缓解高血糖。
