Perez G, Kemmer F W, Lickley H L, Vranic M
Am J Physiol. 1981 Oct;241(4):E328-35. doi: 10.1152/ajpendo.1981.241.4.E328.
In normal dogs epinephrine stimulates glucose production (Ra) independently of glucagon. To investigate the role of this interaction in diabetes, epinephrine (0.1 micrograms . kg-1 . min-1) was infused for 90 min in five alloxan-diabetic dogs in the presence or absence of somatostatin (0.1 micrograms . kg-1 . min-1). In response to epinephrine, glycemia rose by 40% reflecting a near maximal (122%) increase in Ra. Plasma glucagon (IRG) rose to 953 pg/ml, whereas insulin (IRI) increased minimally. When somatostatin was infused with epinephrine to prevent the rise of IRG and IRI, there was only a marginal increase of glucose concentration (12%) and production (38%). The effect of somatostatin was reversed by infusing glucagon (10 ng . kg-1 . min-1) together with epinephrine and somatostatin into five additional alloxan-diabetic dogs. Increments in IRG, glycemia, and Ra were fully reestablished. A 100% FFA increase was observed in all three groups, indicating that the lipolytic effect of epinephrine was independent of glucagon. In conclusion, in diabetic dogs, in contrast to normal dogs, epinephrine induced a marked and prolonged increase in glucose concentration and production mostly through a stimulation of IRG secretion.
在正常犬中，肾上腺素可独立于胰高血糖素刺激葡萄糖生成（Ra）。为研究这种相互作用在糖尿病中的作用，在五只四氧嘧啶糖尿病犬中，于有无生长抑素（0.1微克·千克⁻¹·分钟⁻¹）存在的情况下，输注肾上腺素（0.1微克·千克⁻¹·分钟⁻¹）90分钟。对肾上腺素的反应是，血糖升高40%，反映出Ra近乎最大程度（122%）的增加。血浆胰高血糖素（IRG）升至953皮克/毫升，而胰岛素（IRI）仅有微小增加。当生长抑素与肾上腺素一起输注以防止IRG和IRI升高时，血糖浓度仅略有增加（12%），葡萄糖生成增加（38%）。通过在另外五只四氧嘧啶糖尿病犬中同时输注胰高血糖素（10纳克·千克⁻¹·分钟⁻¹）、肾上腺素和生长抑素，生长抑素的作用被逆转。IRG、血糖和Ra的增加完全恢复。三组均观察到游离脂肪酸增加100%，表明肾上腺素的脂解作用独立于胰高血糖素。总之，与正常犬相比，在糖尿病犬中，肾上腺素主要通过刺激IRG分泌诱导血糖浓度和生成显著且持续的增加。
