Welch W D, Spurgeon L, Kitts D, Moyed H S, Thrupp L D
J Clin Microbiol. 1981 Mar;13(3):606-8. doi: 10.1128/jcm.13.3.606-608.1981.
Of 50 strains of Escherichia coli isolated from blood cultures of bacteremic patients, 14 (28%) were unable to grow on minimal medium at 42 degrees C, compared to only 2 of 50 nonbacteremic strains. In 7 of the 14 bacteremic strains, growth at 42 degrees C was restored by adding nicotinic acid. These unique temperature-sensitive auxotrophic patterns warrant evaluation as a marker correlating with clinical pathogenicity in E. coli.
从菌血症患者血培养物中分离出的50株大肠杆菌中,有14株(28%)在42℃的基本培养基上无法生长,相比之下,50株非菌血症菌株中只有2株如此。在这14株菌血症菌株中,有7株通过添加烟酸恢复了在42℃的生长。这些独特的温度敏感型营养缺陷型模式值得作为一种与大肠杆菌临床致病性相关的标志物进行评估。