Sud I J, Feingold D S
J Invest Dermatol. 1981 Jun;76(6):438-41. doi: 10.1111/1523-1747.ep12521036.
The mechanism of the antifungal action of the imidazole antimycotics, miconazole ano clotrimazole, on Saccharomyces cerevisiae was explored. When grown aerobically both drugs were fungistatic at low concentrations and fungicidal at high concentrations. When grown anaerobically the fungistatic effect was not seen, but killing still occurred at high concentrations. The fungistatic effect correlated with inhibition of ergosterol synthesis and elevated lanosterol/ergosterol ratios in the organisms. The fungicidal effect involved rapid membrane damage and was unrelated to the imidazole-induced block in ergosterol synthesis. These agents each have 2 distinct antifungal actions.
探讨了咪唑类抗真菌药咪康唑和克霉唑对酿酒酵母的抗真菌作用机制。在需氧条件下生长时，两种药物在低浓度时呈抑菌作用，高浓度时呈杀菌作用。在厌氧条件下生长时，未见抑菌作用，但高浓度时仍有杀菌作用。抑菌作用与麦角固醇合成受抑制及菌体中羊毛固醇/麦角固醇比值升高有关。杀菌作用涉及快速的膜损伤，且与咪唑诱导的麦角固醇合成受阻无关。这些药物各自具有两种不同的抗真菌作用。
