特异性抗体和补体调理作用对中性粒细胞硝基蓝四氮唑（NBT）还原的影响。一项方法学研究及临床应用。

The influence of opsonization with specific antibody and complement on the nitroblue tetrazolium (NBT) reduction of neutrophil granulocytes. A methodological study and a clinical application.

作者信息

Urban T, Jarstrand C, Tunevall G

出版信息

J Clin Lab Immunol. 1981 May;5(3):175-9.

Abstract

The NBT reduction of granulocytes, increased in the presence of bacteria, was further enhanced bl specific antibody. The enhancement was dose-dependent and increased by complement. Clinically, the NBT test was used for measuring specific antibody in sera from patients after severe infections. With sera from 10 out of 14 patients with proven or suspected septicemia the NBT reduction was enhanced because of the presence of specific antibody. These results correlated well with the bacteriological findings and supported the view that the bacteria isolated from blood were relevant for the disease.

摘要

粒细胞的NBT还原在有细菌存在时会增加，而特异性抗体可使其进一步增强。这种增强呈剂量依赖性，且补体可使其增加。临床上，NBT试验用于检测重症感染患者血清中的特异性抗体。在14例已证实或疑似败血症患者中，有10例患者的血清因存在特异性抗体而使NBT还原增强。这些结果与细菌学检查结果高度相关，支持了从血液中分离出的细菌与疾病相关的观点。

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