Prevalence of antibodies to parasitic infections in Nigerian children.

Sixty-six sera from Nigerian children who attended a paediatric clinic at University College Hospital, Ibadan were tested with Plasmodium falciparum, P. brazilianum, Entamoeba histolytica, Toxoplasma gondii and Schistosoma mansoni antigens using indirect fluorescent antibody technique. These sera were tested using ELISA technique for Schistosoma antibodies. Sera from all proven cases of infections gave positive results. Highest antibody prevalence rate was for P. falciparum (69.6%), followed by P. malariae (63.6%) and E. histolytica (42.4%) infections. About 17% and 16% were reactive with Toxoplasma and Schistosoma antigens respectively. Only nine (13.6%) children were negative with all antigens. Forty-four (66.6%) children were positive to two or more parasitic antibodies indicating exposure to those diseases. The significance of these antibodies in children is discussed.