Motomiya T, Yamazaki H
Jpn Circ J. 1981 Jun;45(6):680-6. doi: 10.1253/jcj.45.680.
Male SHR of young prehypertensive (5-6 weeks) and mature hypertensive (24-28 weeks) ages and age and sex matched control normotensive Wistar rats (NWR) were studied for aortic smooth muscle contractility in response to rabbit aorta contracting substance (RCS), serotonin, norepinephrine and potassium. Production of prostacyclin (PGI2) in SHR and NWR aortae of these two age groups was also compared. The contractility of young SHR in response to the agonists was all depressed as compared with the matched NWR. With age advances to 24-28 weeks, aortic responsiveness of NWR to all agonists were reduced and the contractility became the same for SHR and NWR except for the response to RCS which was now greater in SHR than in NWR. The PGI2-like substance released from young SHR aortae was the same as that from the matched NWR. The PGI2-like substance in mature aged rat aortae was much higher than that in young rat aortae and the activity in mature SHR was 1.8 times higher than that of the age matched NWR. The increased production of PGI2-like substance in aorta walls of the mature aged SHR may be a compensatory mechanism to reduce the elevated blood pressure.
研究了年轻的高血压前期（5 - 6周）和成熟的高血压（24 - 28周）年龄阶段的雄性自发性高血压大鼠（SHR）以及年龄和性别匹配的对照正常血压Wistar大鼠（NWR）对兔主动脉收缩物质（RCS）、血清素、去甲肾上腺素和钾的主动脉平滑肌收缩性。还比较了这两个年龄组的SHR和NWR主动脉中前列环素（PGI2）的产生情况。与匹配的NWR相比，年轻SHR对激动剂的收缩性均降低。随着年龄增长到24 - 28周，NWR对所有激动剂的主动脉反应性降低，除了对RCS的反应SHR现在大于NWR外，SHR和NWR的收缩性变得相同。从年轻SHR主动脉释放的类PGI2物质与匹配的NWR相同。成熟大鼠主动脉中的类PGI2物质远高于年轻大鼠主动脉，成熟SHR中的活性比年龄匹配的NWR高1.8倍。成熟老年SHR主动脉壁中类PGI2物质产生的增加可能是一种降低升高血压的代偿机制。
