胆钙化醇治疗对自发性高血压大鼠主动脉膜电位和收缩性的影响。
Effect of treatment with cholecalciferol on the membrane potential and contractility of aortae from spontaneously hypertensive rats.
作者信息
Silva E G, Vianna L M, Okuyama P, Paiva T B
机构信息
Department of Biophysics, Escola Paulista de Medicina, São Paulo, Brazil.
出版信息
Br J Pharmacol. 1996 Jul;118(6):1367-70. doi: 10.1111/j.1476-5381.1996.tb15546.x.
Abstract
- The diet of spontaneously hypertensive rats (SHR) and normotensive Wistar rats (NWR) was supplemented with 12.5 micrograms cholecalciferol per 100 g body weight daily, by gavage, for 4 weeks. 2. The amplitude of the contractile responses of aortic rings from SHR to potassium and adrenaline, which was smaller than in NWR aortae, was increased after treatment with cholecalciferol. No further changes were observed in the responses of NWR and SHR aortae in the presence of 100 nM apamin. 3. The membrane potentials of aortae from SHR, which were higher than those of aortae from NWR, decreased after treatment with cholecalciferol. Further depolarization was observed in aortic rings from NWR, but not in aortic rings from SHR, after their preincubation with 100 nM apamin. 4. It is concluded that cholecalciferol normalizes the membrane potential and contractility of aortae from SHR, probably through an effect on lipid composition and structure of the plasma membrane.
摘要
- 通过灌胃，每天给自发性高血压大鼠（SHR）和正常血压的Wistar大鼠（NWR）补充每100克体重12.5微克胆钙化醇，持续4周。2. SHR主动脉环对钾和肾上腺素的收缩反应幅度小于NWR主动脉环，经胆钙化醇治疗后该幅度增加。在存在100 nM蜂毒明肽的情况下，未观察到NWR和SHR主动脉的反应有进一步变化。3. SHR主动脉的膜电位高于NWR主动脉，经胆钙化醇治疗后降低。在NWR的主动脉环预孵育100 nM蜂毒明肽后，观察到进一步去极化，但SHR的主动脉环未出现。4. 得出结论，胆钙化醇可能通过对质膜脂质组成和结构的影响，使SHR主动脉的膜电位和收缩性正常化。
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