Calatayud M, Peña P, Martínez P, Bermejo F, Alvarez Tejerina J
Med Clin (Barc). 1981 May 10;76(9):396-400.
A series of 100 epileptic patients in whom the incidence of toxic effects due to antiepileptic drugs was retrospectively studied form the basis of this report. The appearance of toxic effects depended mainly on the number of drugs used, the length of therapy and the evolution of the epileptic crisis; they were more important in focal epilepsies, which were those with more resistance to therapeutic control and requiring increasing number and doses of antiepileptic drugs. Some side effects were observed in 60% of the patients involving generally the nervous system, skin, connective tissue, skeletal system, and hematopoietic organs. The drugs had to be reduced in 19% of these patients because of excessive sedation, mild central nervous system intoxication and various psychological effects, while treatment had to be changed in 11% due to acute intoxication with skin involvement, hematologic alterations and excessive sedation.
本报告基于对100例癫痫患者进行回顾性研究所得出的抗癫痫药物毒性作用发生率。毒性作用的出现主要取决于所用药物的数量、治疗时间长短以及癫痫发作的演变过程；在局灶性癫痫中更为显著，这类癫痫对治疗控制的抵抗性更强，需要增加抗癫痫药物的种类和剂量。60%的患者出现了一些副作用，通常涉及神经系统、皮肤、结缔组织、骨骼系统和造血器官。在这些患者中，19%因过度镇静、轻度中枢神经系统中毒及各种心理效应而不得不减少药物用量，11%因皮肤受累、血液学改变及过度镇静导致的急性中毒而不得不更换治疗方案。
