De Negri M, Doria L, Gaggero R, Rolando S
Pediatr Med Chir. 1981 Mar-Jun;3(2-3):159-64.
Neurological and psychic side effects of anticonvulsivant drugs in pediatric age are separately considered. Neurological side effects are classified according to different ages: in the neonatal period sedation is preeminent, later psychomotor deterioration or cerebellar and/or extrapyramidal signs may occur. Less frequently antiepileptic drugs are responsible of worsening of seizures up to a toxic encephalopathy. Psychic side effects are more variable and unpredicatable. The same drugs can cause both psychomotor excitement or psychic slowness. In a few instances psychotic syndromes can be observed. Very important are chronic side effects on intellectual activities, especially in children. Finally some factors which can affect the interpretation of the side effects have to be considered: pharmacokinetic data individual reactivity, methodology of evaluation of clinical symptoms, especially psychic ones.
抗惊厥药物在儿童期的神经和精神副作用分别进行讨论。神经副作用根据不同年龄分类：在新生儿期，镇静作用最为突出，之后可能出现精神运动发育迟缓或小脑和/或锥体外系体征。抗癫痫药物较少导致癫痫发作加重直至中毒性脑病。精神副作用则更为多样且不可预测。相同的药物可能导致精神运动兴奋或精神迟钝。在少数情况下可观察到精神病综合征。对智力活动的慢性副作用非常重要，尤其是在儿童中。最后，必须考虑一些可能影响副作用解释的因素：药代动力学数据、个体反应性、临床症状评估方法，尤其是精神症状的评估方法。
