Gebhart D E
Laryngoscope. 1981 Jun;91(6):849-66. doi: 10.1288/00005537-198106000-00001.
Otitis media has long been recognized as one of the most common diseases of childhood. A prospective randomized study was designed with patients who had multiple episodes of acute purulent otitis media. Comparison of infection rates was made between patients treated with conventional antibiotic therapy for each episode and patients who had tympanostomy tubes placed. Placement of tympanostomy tubes significantly decreased the number of episodes of acute purulent otitis media and was shown to be an effective method of prophylaxis in the "otitis prone" child. Immunoglobulin levels in the middle ear in this group of patients were found to be similar to those levels in patients with otitis media with effusion. This supports the hypothesis that a dynamic relationship between the different clinical entities of otitis media exists.
中耳炎长期以来一直被认为是儿童最常见的疾病之一。一项前瞻性随机研究针对患有多次急性化脓性中耳炎的患者设计。对每次发作接受传统抗生素治疗的患者与置入鼓膜造孔管的患者的感染率进行了比较。置入鼓膜造孔管显著减少了急性化脓性中耳炎的发作次数,并被证明是预防“易患中耳炎”儿童的有效方法。发现这组患者中耳的免疫球蛋白水平与中耳积液患者的水平相似。这支持了中耳炎不同临床实体之间存在动态关系的假设。