Monges B, Remacle J P, Monges G, Payan H
Pathol Biol (Paris). 1981 Mar;29(3):143-9.
Electron microscopic observation of sera from 59 subjects(HBs Ag-negative controls, HBs Ag-positive asymptomatic blood donors, and HBs Ag-positive patients with acute viral hepatitis, chronic persistant or active hepatitis and alcohol-induced liver damage) was capable of specifying the morphology of the HB virus (spherical particles, rod-shaped particles and Dane particles) and of correlating the aspect of the observed viral material with the nature and evolution of the liver damage. The viral particles are observed in small amounts in asymptomatic blood donors and in patients with acute viral hepatitis, but are present in very significant quantities in chronic hepatitis. Dane particles and viral particle aggregates are more numerous in chronic active hepatitis than in chronic persistant hepatitis. The detection of HBeAg in the serum, especially found in chronic active hepatitis, correlates with the presence of Dane particles. In most cases, the observed viral particle aggregates do not seem to be associated with an immunological process.
对59名受试者（乙肝表面抗原阴性对照者、乙肝表面抗原阳性无症状献血者以及乙肝表面抗原阳性的急性病毒性肝炎、慢性持续性或活动性肝炎和酒精性肝损伤患者）的血清进行电子显微镜观察，能够明确乙肝病毒的形态（球形颗粒、杆状颗粒和Dane颗粒），并能将观察到的病毒物质的情况与肝损伤的性质和演变联系起来。在无症状献血者和急性病毒性肝炎患者中可少量观察到病毒颗粒，但在慢性肝炎患者中病毒颗粒数量非常可观。Dane颗粒和病毒颗粒聚集体在慢性活动性肝炎中比在慢性持续性肝炎中更多。血清中HBeAg的检测，尤其在慢性活动性肝炎中发现，与Dane颗粒的存在相关。在大多数情况下，观察到的病毒颗粒聚集体似乎与免疫过程无关。
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