Erwin V G, McClearn G E, Kuse A R
Pharmacol Biochem Behav. 1980;13 Suppl 1:297-302. doi: 10.1016/s0091-3057(80)80045-1.
Voluntary alcohol consumption, acute tolerance, and central nervous system (CNS) sensitivity to ethanol are potentially informative measures concerning human alcoholism. Little is understood regarding the associations among these parameters or between these traits and neurochemical processes such as brain protein or brain enzyme activities. A powerful strategy is to assess a large number of characteristics simultaneously on all individuals as a heterogeneous sample. This permits rapid screening of a large number of variables with respect to their interrelationships. Identification can thus be made of those variables that are elements of the caudal nexus, and subsequent experimental research can attack the problem of identifying mechanisms. The present study employed mice from the HS/Ibg stock which is maintained by systematic random mating to assure genetic heterogeneity. The results demonstrate that voluntary ethanol consumption and acquisition of acute tolerance to ethanol were positively associated, whereas these measures were not significantly related to CNS sensitivity to ethanol. In addition, ethanol preference was inversely related to soluble brain protein. The activities of the soluble enzymes from brain, aldehyde reductase and glucose-6-phosphate dehydrogenase, were not significantly associated with ethanol preference, acquisition of acute tolerance, or CNS sensitivity to ethanol. Unexpectedly, more than 30 percent of the variance in voluntary alcohol consumption could have been predicted from the measurements of acquisition of acute tolerance, and vice versa.
自愿饮酒、急性耐受性以及中枢神经系统（CNS）对乙醇的敏感性是与人类酒精中毒相关的潜在有用指标。关于这些参数之间的关联，或者这些特征与神经化学过程（如脑蛋白或脑酶活性）之间的关联，目前了解甚少。一种有效的策略是将所有个体作为一个异质样本同时评估大量特征。这允许快速筛选大量变量之间的相互关系。由此可以确定那些是尾端联系要素的变量，随后的实验研究可以着手解决识别机制的问题。本研究使用了通过系统随机交配维持的HS/Ibg品系小鼠，以确保遗传异质性。结果表明，自愿乙醇摄入量与对乙醇急性耐受性的获得呈正相关，而这些指标与CNS对乙醇的敏感性无显著相关性。此外，乙醇偏好与可溶性脑蛋白呈负相关。脑可溶性酶醛还原酶和葡萄糖-6-磷酸脱氢酶的活性与乙醇偏好、急性耐受性的获得或CNS对乙醇的敏感性均无显著关联。出乎意料的是，自愿饮酒量超过30%的变异可以通过急性耐受性获得的测量来预测，反之亦然。
