Namboodiri M A, Favilla J T, Klein D C
Science. 1981 Jul 31;213(4507):571-3. doi: 10.1126/science.7017937.
Pineal N-acetyltransferase can be inactivated in broken cell preparations by cystamine through a mechanism of thiol-disulfide exchange. Some, but not all, disulfide-containing peptides can inactivate this enzyme; the most potent inactivator is insulin. These findings suggest that a disulfide-containing peptide with high reactivity toward N-acetyltransferase may participate in the intracellular regulation of this enzyme.
松果体N - 乙酰基转移酶在破碎细胞制剂中可被胱胺通过硫醇 - 二硫键交换机制使其失活。一些（但不是全部）含二硫键的肽可以使这种酶失活；最有效的失活剂是胰岛素。这些发现表明，一种对N - 乙酰基转移酶具有高反应活性的含二硫键肽可能参与该酶的细胞内调节。
