Messiha F S, Hutson J
Arch Androl. 1981 May;6(3):243-8. doi: 10.3109/01485018108987535.
The distribution of both alcohol (ADH) and aldehyde-dehydrogenase (ALDH) was studied in the rat testis. Testicular ADH was mainly localized into the interstitial tissue. Testicular ALDH activity was distributed between the interstitial tissue and the seminiferous tubules with greater activity measured in the former component. The apparent Km for ADH in the whole testis was greater than that measured in the interstitial tissue. A low Km value was determined for ALDH in the seminiferous tubules, compared to a higher mean Km value for this enzyme in the interstitial tissue of the testis. The study shows that interstitial tissue possesses both ADH and ALDH, which are essential for the respective metabolism of ethanol and acetaldehyde, and that the seminiferous tubules possesses greater affinity for the metabolism of acetaldehyde than that of the interstitial tissue.
对大鼠睾丸中乙醇脱氢酶（ADH）和乙醛脱氢酶（ALDH）的分布进行了研究。睾丸ADH主要定位于间质组织。睾丸ALDH活性分布于间质组织和生精小管之间，前者的活性更高。整个睾丸中ADH的表观Km值大于间质组织中的测定值。与睾丸间质组织中该酶较高的平均Km值相比，生精小管中ALDH的Km值较低。该研究表明，间质组织同时拥有ADH和ALDH，它们分别是乙醇和乙醛代谢所必需的，并且生精小管对乙醛代谢的亲和力大于间质组织。
