在紫外线存在的情况下，三甲基补骨脂素比8-甲氧基补骨脂素对姐妹染色单体交换的促进作用更强。

Greater promotion in sister chromatid exchanges by trimethylpsoralen than by 8-methoxypsoralen in the presence of UV-light.

作者信息

Gaynor A L, Carter D M

出版信息

J Invest Dermatol. 1978 Oct;71(4):257-9. doi: 10.1111/1523-1747.ep12515098.

Abstract

The number of sister chromatid exchanges (SCEs) was determined in normal human leukocytes following exposure in vitro to UV light (365 nm, UV-A) and either 8-methoxypsoralen (8-MOP) or 4,5'8 trimethylpsoralen (TMP). Both psoralens produced an increase in SCEs, proportional to UV dose and concentration of drug. Neither drug alone nor UV alone promoted SCEs. The number of SCEs per cell was greater in leukocytes irradiated in the presence of TMP than in the presence of equimolar 8-MOP. At equimolar concentrations, TMP formed more cross-links than did 8-MOP. The difference in the effects of these 2 agents on various cell functions may relate to quantitative and qualitative differences in the photoadducts they form.

摘要

在体外将正常人白细胞暴露于紫外线（365nm，UV-A）以及8-甲氧基补骨脂素（8-MOP）或4,5',8-三甲基补骨脂素（TMP）后，测定姐妹染色单体交换（SCE）的数量。两种补骨脂素均使SCE数量增加，且与紫外线剂量和药物浓度成正比。单独使用任何一种药物或单独使用紫外线均不会促进SCE。在TMP存在下照射的白细胞中，每个细胞的SCE数量比在等摩尔8-MOP存在下照射的白细胞更多。在等摩尔浓度下，TMP形成的交联比8-MOP更多。这两种药物对各种细胞功能的影响差异可能与它们形成的光加合物在数量和质量上的差异有关。