Gebhart E
Hum Genet. 1981;58(3):235-54. doi: 10.1007/BF00294917.
Data from previous studies published on the induction by mutagens of sister chromatid exchanges (SCEs) and structural chromosome damage were compared qualitatively and quantitatively. Although a good correlation between the incidence of both cytogenetic phenomena has been pointed out in many previous publications, about 30% of the agents for which comparable data were available yielded non-corresponding qualitative results concerning both indicator effects. However, even in groups with good qualitative agreement distinct quantitative differences indicated different molecular mechanisms of the formation of SCEs and breaks. Additional information supporting the importance of these differences for the validity of both indicator systems has been derived from the results obtained using strong clastogens exhibiting a low or no SCE-inducing activity and vice versa, from special observations on chromosomal breakage syndromes, and from studies on the action of known co- and anti-clastogens on SCE-induction by chemical mutagens. As a result, it has been suggested that the SCE-technique should be considered as a valuable additional method for cytogenetic mutagenicity testing, which, however, is not adequate to replace the classical methods of analysis of structural chromosome damage.
对以往发表的关于诱变剂诱导姐妹染色单体交换（SCEs）和染色体结构损伤的数据进行了定性和定量比较。尽管在许多先前的出版物中都指出这两种细胞遗传学现象的发生率之间存在良好的相关性，但在可获得可比数据的试剂中，约30%的试剂在两种指标效应方面产生了不对应的定性结果。然而，即使在定性一致性良好的组中，明显的定量差异也表明SCEs和断裂形成的分子机制不同。使用具有低SCE诱导活性或无SCE诱导活性的强断裂剂获得的结果，以及对染色体断裂综合征的特殊观察结果，以及关于已知的协同和抗断裂剂对化学诱变剂诱导SCE的作用的研究结果，都为支持这些差异对两种指标系统有效性的重要性提供了额外信息。结果表明，SCE技术应被视为细胞遗传毒性测试中有价值的补充方法，然而，它不足以取代分析染色体结构损伤的经典方法。
