8-甲氧基补骨脂素与紫外线对姐妹染色单体交换的急性效应
Acute effect of 8-methoxypsoralen and ultraviolet light on sister chromatid exchange.
作者信息
Wulf H C
出版信息
Arch Dermatol Res. 1978 Sep 28;263(1):37-46.
The acute effect of 8-methoxypsoralen (8-MOP) and 8-MOP + long wave ultraviolet light (UVA) on sister chromatid exchange (SCE) has been examined in an in vitro experiment. The SCE count was significantly increased by 8-MOP without light, but the effect was substantially greater (50%) by 8-MOP + UVA. In addition, mitoses with banded staining of the chromosomes were seen after 8-MOP and UVA. These changes were dose dependent, and they might be responsible for the reduced cell turnover in psoriasis plaque after PUVA.
在一项体外实验中，研究了8-甲氧基补骨脂素（8-MOP）以及8-甲氧基补骨脂素+长波紫外线（UVA）对姐妹染色单体交换（SCE）的急性影响。无光照时，8-MOP可使SCE计数显著增加，但8-MOP+UVA的作用则显著更强（增加50%）。此外，在使用8-MOP和UVA后，可见染色体呈带纹染色的有丝分裂。这些变化具有剂量依赖性，它们可能是导致光化学疗法（PUVA）后银屑病斑块中细胞更新减少的原因。
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