Quinn M A, Murphy A J, Kuhn R J, Robinson H P, Brown J B
Br J Obstet Gynaecol. 1981 Jun;88(6):644-9. doi: 10.1111/j.1471-0528.1981.tb01223.x.
Forty nulliparous patients with Bishop score of 3 or less were given 15 mg oestriol gel, 10 mg PGF2 alpha gel or gel alone via the extra-amniotic route. Both the oestriol and prostaglandin treated patients had a significant increase in Bishop score and a significant reduction in induction-delivery interval compared to controls. Oestriol gel had significantly less stimulatory effect on uterine activity than prostaglandin gel, indicating a possible local action.
40例未产妇，其Bishop评分小于或等于3，通过羊膜外途径给予15mg雌三醇凝胶、10mg前列腺素F2α凝胶或单纯凝胶。与对照组相比，雌三醇和前列腺素治疗组患者的Bishop评分均显著增加，引产至分娩间隔显著缩短。雌三醇凝胶对子宫活动的刺激作用明显小于前列腺素凝胶，表明可能存在局部作用。
