芘醌作为鼠伤寒沙门氏菌致突变性增强剂的代谢形成
Metabolic formation of pyrenequinones as enhancing agents of mutagenicity in Salmonella.
作者信息
Okamoto H, Yoshida D
出版信息
Cancer Lett. 1981 Jan;11(3):215-20. doi: 10.1016/0304-3835(81)90110-5.
PMID:7018664
Abstract
Pyrene and 1-methylpyrene in the pyrolysis product of cellulose, which enhances mutagenicity of 2-acetylaminofluorene, must be metabolized to expose enhancing activity. 1,6-Pyrenequinone and 1,8-pyrenequinone, having high enhancement activity, were first isolated and identified in the metabolites of pyrene by rat liver microsomal fraction.
摘要
纤维素热解产物中的芘和1-甲基芘可增强2-乙酰氨基芴的致突变性，必须经过代谢才能表现出增强活性。具有高增强活性的1,6-芘醌和1,8-芘醌首先在大鼠肝脏微粒体组分对芘的代谢产物中被分离和鉴定出来。
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