Okamoto H, Yoshida D
Cancer Lett. 1981 May;12(4):323-7. doi: 10.1016/0304-3835(81)90174-9.
1-Hydroxypyrene and 4,5-dihydro-4,5-dihydro-4,5-dihydroxypyrene were isolated and identified in the metabolites of pyrene by rat liver microsomal fraction, and the presence of 1,8- and 1,6-dihydroxypyrene in the metabolites was proposed. These hydroxypyrenes, as well as pyrenequinones reported previously, enhanced intensively the mutagenicity of 2-acetylaminofluorene (AAF).
1-羟基芘和4,5-二氢-4,5-二羟基芘在大鼠肝脏微粒体组分对芘的代谢产物中被分离并鉴定出来，并且推测代谢产物中存在1,8-二羟基芘和1,6-二羟基芘。这些羟基芘，以及先前报道的芘醌，显著增强了2-乙酰氨基芴（AAF）的致突变性。
