Lebel M, Lachance J G, Grose J H
Biomedicine. 1981 Jul;35(3):81-4.
Plasma renin activity (PRA) was measured after repetitive furosemide stimulations in 16 normotensive homotransplanted patients who previously had bilateral nephrectomies. The percentage PRA response to furosemide was very low (34%) in the immediate period after transplantation, but increased progressively with time to a level after one year (111%) which was not statistically different from age and sex matched control subjects. A significant correlation was found between the percentage PRA increase and the number of weeks after transplantation (r = 0.48, P less than 0.01). These data indicate that the juxtaglomerular cell responsiveness to furosemide is quantitatively time dependent after transplantation, and it is a factor that should be considered in the evaluation of renin-angiotensin system in such patients.
对16例曾行双侧肾切除术的血压正常的同种肾移植患者，在反复给予速尿刺激后测定血浆肾素活性（PRA）。移植后即刻，PRA对速尿的反应百分比非常低（34%），但随时间逐渐升高，至一年后达到一个水平（111%），与年龄和性别匹配的对照受试者相比无统计学差异。发现PRA升高百分比与移植后周数之间存在显著相关性（r = 0.48，P < 0.01）。这些数据表明，移植后肾小球旁细胞对速尿的反应性在数量上与时间相关，这是评估此类患者肾素 - 血管紧张素系统时应考虑的一个因素。
