Moncada S, Vane J R
Drugs. 1981 Jun;21(6):430-7. doi: 10.2165/00003495-198121060-00002.
Prostacyclin is a potent but unstable vasodilator, and inhibitor of platelet aggregation, which is produced by blood vessel walls. Platelet aggregability may be constantly conditioned in vivo by local or circulating prostacyclin. Prostacyclin is important in the maintenance of vascular homeostasis and may be implicated in certain disease states. The use of prostacyclin in antithrombotic therapy appears logical, considering its action in increasing platelet cyclic AMP and reducing aggregation; its potential in antithrombotic therapy is presently being explored.
前列环素是一种强效但不稳定的血管扩张剂和血小板聚集抑制剂，由血管壁产生。血小板聚集性在体内可能受局部或循环中的前列环素持续调节。前列环素在维持血管稳态方面很重要，可能与某些疾病状态有关。鉴于前列环素在增加血小板环磷酸腺苷和减少聚集方面的作用，其在抗血栓治疗中的应用似乎是合理的；目前正在探索其在抗血栓治疗中的潜力。
