Zaczek R, Collins J, Coyle J T
Neurosci Lett. 1981 Jul 2;24(2):181-6. doi: 10.1016/0304-3940(81)90245-7.
N-Methyl-D-aspartic acid (NMDA) is 100-fold less potent as a neurotoxin than kainic acid when injected into the rat striatum. However, NMDA, when injected into the hippocampus, causes a more severe seizure disorder than kainic acid and doses of NMDA than produce much smaller lesions than those caused by kainate. These results indicate a poor correlation between convulsant and neurotoxic properties of acidic excitatory amino acids.
当注射到大鼠纹状体中时，N-甲基-D-天冬氨酸（NMDA）作为神经毒素的效力比红藻氨酸低100倍。然而，当注射到海马体中时，NMDA比红藻氨酸会导致更严重的癫痫发作紊乱，并且NMDA的剂量所产生的损伤比红藻氨酸引起的损伤小得多。这些结果表明酸性兴奋性氨基酸的惊厥特性和神经毒性特性之间的相关性较差。
