Reddy J, Bailey R R
N Z Med J. 1981 May 27;93(684):337-9.
Two elderly women suffered an acute deterioration of renal function after treatment with cefoxitin sodium. One with stable chronic renal failure due to reflux nephropathy underwent a rapid deterioration of renal function which proved fatal. The other woman had rheumatoid arthritis and developed acute tubular necrosis after treatment with gentamicin and cefoxitin. All the data suggested that the antibiotic was responsible for the deterioration in renal function. The dose of cefoxitin should be reduced in patients with renal functional impairment. Cefoxitin should either be used with great caution or not prescribed in combination with aminoglycoside antibiotics.
两名老年女性在使用头孢西丁钠治疗后出现肾功能急性恶化。其中一名因反流性肾病导致慢性肾功能稳定的患者，肾功能迅速恶化并最终死亡。另一名患有类风湿性关节炎的女性在使用庆大霉素和头孢西丁治疗后发生急性肾小管坏死。所有数据表明，抗生素是导致肾功能恶化的原因。肾功能损害患者应减少头孢西丁的剂量。使用头孢西丁时应极其谨慎，或不应与氨基糖苷类抗生素联合使用。
