Johnston R B
Rev Infect Dis. 1981 Mar-Apr;3(2):282-8. doi: 10.1093/clinids/3.2.282.
In vitro studies and analyses of the immunodeficiency disorders that predispose to infection with Streptococcus pneumoniae indicate that efficient phagocytosis is essential for protection against this organism. Thus, antibody- and C3b-dependent opsonization and the process of ingestion, not cell-mediated immunity or post-phagocytic killing mechanisms, are stressed. It is likely that the tissue damage of pneumococcal disease also results from the interactions between antibody, complement, and phagocytic cells that permit ingestion. More effective protection against pneumococcal invasion and better management of pneumococcal disease depend on improved understanding of these interactions.
对易感染肺炎链球菌的免疫缺陷疾病进行的体外研究和分析表明，有效的吞噬作用对于抵御该病原体至关重要。因此，强调的是抗体和C3b依赖性调理作用以及摄取过程，而非细胞介导的免疫或吞噬后杀伤机制。肺炎球菌疾病的组织损伤可能也源于允许摄取的抗体、补体和吞噬细胞之间的相互作用。更好地抵御肺炎球菌入侵以及更有效地管理肺炎球菌疾病，取决于对这些相互作用的进一步了解。
