补体的首个成分。对人上皮细胞和间充质细胞在培养中其生物合成的定量比较。
The first component of complement. A quantitative comparison of its biosynthesis in culture by human epithelial and mesenchymal cells.
作者信息
Morris K M, Colten H R, Bing D H
出版信息
J Exp Med. 1978 Oct 1;148(4):1007-19. doi: 10.1084/jem.148.4.1007.
Abstract
Epithelial and mesenchymal cells synthesized and secreted all three subcomponents of the first component of complement (C1): C1q, C1r, and C1s. Quantitatively, however, columnar and transitional epithelial cells secreted 400--3,700 times more hemolytically active C1 than monocytes or fibroblasts. Only columnar epithelial cells synthesized C1 subcomponents with subunit structures similar to their serum counterparts. Transitional epithelial cells, fibroblasts, and monocytes produced C1q and C1s with subunits of apparent molecular weights larger than reported values. C1r from all cell lines was physiochemically similar to serum C1r.
摘要
上皮细胞和间充质细胞合成并分泌补体第一成分（C1）的所有三个亚成分：C1q、C1r和C1s。然而，从数量上看，柱状上皮细胞和移行上皮细胞分泌的具有溶血活性的C1比单核细胞或成纤维细胞多400 - 3700倍。只有柱状上皮细胞合成的C1亚成分具有与其血清对应物相似的亚基结构。移行上皮细胞、成纤维细胞和单核细胞产生的C1q和C1s的亚基表观分子量大于报道值。所有细胞系的C1r在物理化学性质上与血清C1r相似。
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3
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4
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Proc Natl Acad Sci U S A. 1966 Oct;56(4):1158-63. doi: 10.1073/pnas.56.4.1158.
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