Smedile G, Pata P, Mancuso T R, Morabito S, Forgione F
Boll Soc Ital Biol Sper. 1981 Mar 15;57(5):518-21.
Basal values of H-Prl have been assayed with reproducible RIA in two accurately selected group of subjects: 1) obese with latent glucose intolerance; 2) obese without glucose intolerance. In these patients have been valued also IRI and blood glucose (GOD-POD Biochemia). The data reported in this paper show that therein't correlation between basal H-Prl values and difference obese -- normal of IRI concentrations neither in non-diabetics nor in pre-diabetics obese. It indicate that the H-Prl not plays a controinsular role in obese-prediabetics subjects. No difference in basal values of H-Prl we found in the examined patient obese pre- and not-diabetics.
已采用可重复的放射免疫分析方法,对两组精心挑选的受试者测定了基础人催乳素(H-Prl)值:1)伴有潜在糖耐量异常的肥胖者;2)无糖耐量异常的肥胖者。还对这些患者的胰岛素释放指数(IRI)和血糖(采用葡萄糖氧化酶-过氧化物酶法测定)进行了评估。本文报道的数据表明,在非糖尿病肥胖者和糖尿病前期肥胖者中,基础H-Prl值与肥胖者和正常人之间IRI浓度的差异均无相关性。这表明H-Prl在肥胖-糖尿病前期受试者中不发挥胰岛控制作用。在检查的糖尿病前期肥胖患者和非糖尿病肥胖患者中,我们未发现基础H-Prl值有差异。