Goldstein K, Rosdahl V T
Chemotherapy. 1981;27(5):313-7. doi: 10.1159/000237998.
79 Escherichia coli strains were investigated by the triple layer technique for the presence of the 'paradoxical zone phenomenon' around an ampicillin disc. 76 strains were positive, 3 negative. 7 positive and 3 negative strains were treated with varying concentrations of ampicillin and counted. Only 5 of the 7 positive strains showed the Eagle effect, all 3 negative strains gave no Eagle effect. The magnitude of the Eagle effect observed is regarded as being of no clinical importance in the treatment of E. coli with high dosages of ampicillin.
采用三层技术对79株大肠杆菌进行了研究，以检测氨苄西林纸片周围是否存在“矛盾区现象”。76株呈阳性，3株呈阴性。对7株阳性菌株和3株阴性菌株用不同浓度的氨苄西林进行处理并计数。7株阳性菌株中只有5株表现出伊格尔效应，所有3株阴性菌株均未表现出伊格尔效应。观察到的伊格尔效应的程度被认为在用高剂量氨苄西林治疗大肠杆菌时无临床意义。
