Montgomery A, Swenarchuk L
J Neurol Sci. 1978 Aug;38(1):77-82. doi: 10.1016/0022-510x(78)90247-2.
Counts of the number of myelinated axons in the nerves to slow-twitch soleus and fast-twitch plantaris muscles of 129 ReJ dy/dy dystrophic mice at 4, 15 and 24 weeks of age have shown statistically significant reductions when compared to normal values. In addition muscle fibre losses had occurred in both muscles at the earliest age point studied. There was no suggestion of a progressive loss of myelinated axons. There was a greater percentage reduction in the soleus than in the plantaris nerves. The number of myelinated axons in the nerves to the plantaris and soleus muscles of the 129 ReJ +/+ normal animals was approximately the same, in contrast to the C57BL/6J strain where the soleus nerve always contained a greater number. Statistically significant reductions in the number of myelinated axons in the nerves to the medial gastrocnemius muscles of C57BL/6J dy2J/dy2J dystrophic mice have been observed at both 15 and 72 weeks of age. Muscle fibre losses have also been recorded in 72 weeks dystrophic medial gastrocnemius muscles.
对129只ReJ dy/dy营养不良小鼠在4周、15周和24周龄时，其支配慢肌比目鱼肌和快肌跖肌的神经中有髓轴突数量的计数显示，与正常值相比，有统计学意义的减少。此外，在研究的最早年龄点，两块肌肉均出现了肌纤维损失。没有迹象表明有髓轴突会逐渐减少。比目鱼肌神经中髓鞘轴突的减少百分比高于跖肌神经。129只ReJ +/+正常动物支配跖肌和比目鱼肌的神经中，有髓轴突数量大致相同，而在C57BL/6J品系中，比目鱼肌神经中的轴突数量总是更多。在15周和72周龄时，均观察到C57BL/6J dy2J/dy2J营养不良小鼠支配腓肠肌内侧的神经中有髓轴突数量有统计学意义的减少。在72周龄的营养不良腓肠肌内侧中也记录到了肌纤维损失。
