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Babesia rodhaini and Plasmodium berghei. A highly active series of chlorophenoxyalkoxy-substituted diamino-dihydrotriazines against experimental infections in mice.

作者信息

Knight D J

出版信息

Ann Trop Med Parasitol. 1981 Feb;75(1):1-6.

PMID:7023398
Abstract
摘要

相似文献

1
Babesia rodhaini and Plasmodium berghei. A highly active series of chlorophenoxyalkoxy-substituted diamino-dihydrotriazines against experimental infections in mice.罗得西亚巴贝斯虫和伯氏疟原虫。一系列对小鼠实验性感染具有高活性的氯苯氧基烷氧基取代二氨基二氢三嗪。
Ann Trop Med Parasitol. 1981 Feb;75(1):1-6.
2
The antimalarial activity of N-benzyl-oxydihydrotriazines. IV. The development of resistance to BRL 6231 (4,6-diamino-1,2-dihyydro-2-,2-dimethyl-1-(2,4,5-trichloropropyloxy)-1,3,5 triazine hydrochloride) by Plasmodium berghei.N-苄基-氧化二氢三嗪的抗疟活性。IV. 伯氏疟原虫对BRL 6231(4,6-二氨基-1,2-二氢-2,2-二甲基-1-(2,4,5-三氯丙氧基)-1,3,5-三嗪盐酸盐)的抗性发展
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The antimalarial activity of N-benzyloxydihydrotriazines. I. The activity of clociguanil (BRL 50216) against rodent malaria, and studies on its mode of action.N-苄氧基二氢三嗪的抗疟活性。I. 氯胍(BRL 50216)对啮齿动物疟疾的活性及其作用方式的研究。
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The antimalarial activity of N-benzyloxydihydrotriazines. II. The development of resistance to clociguanil (BRL 50216) and cycloguanil by P. berghei.N-苄氧基二氢三嗪的抗疟活性。II. 伯氏疟原虫对氯胍(BRL 50216)和环氯胍的抗性发展。
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The antimalarial activity of N-benzyl-oxydihydrotriazines. III. The activity of 4,6-diamino-1,2-dihydro-2,2-dimethyl-1-(2,4,5,-trichloropropyloxy)-1,3,5-triazine hydrobromide (BRL 51084) and hydrochloride (BRL 6231).N-苄基氧化二氢三嗪的抗疟活性。III. 4,6-二氨基-1,2-二氢-2,2-二甲基-1-(2,4,5-三氯丙氧基)-1,3,5-三嗪氢溴酸盐(BRL 51084)和盐酸盐(BRL 6231)的活性
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Transformation with human dihydrofolate reductase renders malaria parasites insensitive to WR99210 but does not affect the intrinsic activity of proguanil.用人类二氢叶酸还原酶进行转化会使疟原虫对WR99210不敏感,但不会影响氯胍的内在活性。
Proc Natl Acad Sci U S A. 1997 Sep 30;94(20):10931-6. doi: 10.1073/pnas.94.20.10931.