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Reversal of inotropic effects of digoxin by specific antibodies and their Fab fragments in the conscious dog.

作者信息

Ochs H R, Vatner S F, Smith T W

出版信息

J Pharmacol Exp Ther. 1978 Oct;207(1):64-71.

PMID:702352
Abstract
摘要

相似文献

1
Reversal of inotropic effects of digoxin by specific antibodies and their Fab fragments in the conscious dog.特异性抗体及其Fab片段对清醒犬地高辛变力作用的逆转
J Pharmacol Exp Ther. 1978 Oct;207(1):64-71.
2
Immunological reversal of the effects of digoxin.地高辛效应的免疫逆转
Fed Proc. 1977 Aug;36(9):2235-41.
3
Effects of sheep digoxin-specific antibodies and their Fab fragments on digoxin pharmacokinetics in dogs.羊地高辛特异性抗体及其Fab片段对犬地高辛药代动力学的影响。
J Clin Invest. 1977 Feb;59(2):345-59. doi: 10.1172/JCI108647.
4
Reversal of advanced digoxin intoxication with Fab fragments of digoxin-specific antibodies.用地高辛特异性抗体Fab片段逆转重度地高辛中毒
N Engl J Med. 1976 Apr 8;294(15):797-800. doi: 10.1056/NEJM197604082941501.
5
Reversal of lethal digoxin toxicity in guinea pigs using monoclonal antibodies and Fab fragments.使用单克隆抗体和Fab片段逆转豚鼠致命性地高辛中毒
J Pharmacol Exp Ther. 1984 Apr;229(1):210-3.
6
Effects of inotropic and arrhythmogenic digoxin doses and of digoxin-specific antibody on myocardial monovalent cation transport in the dog.强心和致心律失常剂量的地高辛以及地高辛特异性抗体对犬心肌单价阳离子转运的影响。
Circ Res. 1979 Jan;44(1):23-31. doi: 10.1161/01.res.44.1.23.
7
Treatment of severe chronic digoxin toxicosis in a dog with cardiac disease, using ovine digoxin-specific immunoglobulin G Fab fragments.使用羊源地高辛特异性免疫球蛋白G Fab片段治疗患有心脏病的犬的严重慢性地高辛中毒。
J Am Vet Med Assoc. 1999 Dec 15;215(12):1808-12, 1806.
8
Reversal of advanced digitoxin toxicity and modification of pharmacokinetics by specific antibodies and Fab fragments.特异性抗体及Fab片段对严重洋地黄毒苷中毒的逆转作用及药代动力学的改变
J Clin Invest. 1977 Dec;60(6):1303-13. doi: 10.1172/JCI108889.
9
Contrasting rates of reversal of digoxin toxicity by digoxin-specific IgG and Fab fragments.地高辛特异性IgG和Fab片段对地高辛毒性的逆转率对比。
Circulation. 1978 Aug;58(2):280-3. doi: 10.1161/01.cir.58.2.280.
10
Fab fragments of digoxin-specific antibodies used to reverse ventricular fibrillation induced by digoxin ingestion in a child.地高辛特异性抗体的Fab片段用于逆转一名儿童因摄入地高辛而诱发的心室颤动。
Pediatrics. 1982 Sep;70(3):468-71.

引用本文的文献

1
Fab antibody fragments: some applications in clinical toxicology.Fab抗体片段：在临床毒理学中的一些应用
Drug Saf. 2004;27(14):1115-33. doi: 10.2165/00002018-200427140-00004.
2
Pharmacokinetic aspects of digoxin-specific Fab therapy in the management of digitalis toxicity.地高辛特异性Fab片段疗法治疗洋地黄中毒的药代动力学方面
Clin Pharmacokinet. 1995 Jun;28(6):483-93. doi: 10.2165/00003088-199528060-00006.
3
Differing sensitivities of Purkinje fibers and myocardium to inhibition of monovalent cation transport by digitalis.
浦肯野纤维和心肌对洋地黄抑制单价阳离子转运的敏感性差异。
J Clin Invest. 1981 Jan;67(1):116-23. doi: 10.1172/JCI110003.
4
Suicidal digoxin poisoning: conventional treatment and antibody therapy.
Klin Wochenschr. 1982 Apr 15;60(8):401-5. doi: 10.1007/BF01735931.
5
The biological properties of immunoglobulin G and its split products [F(ab')2 and Fab].免疫球蛋白G及其裂解产物[F(ab')2和Fab]的生物学特性。
Klin Wochenschr. 1983 Aug 1;61(15):723-36. doi: 10.1007/BF01497399.
6
Proceedings of the Fiftieth Anniversary Meeting of the British Pharmacological Society, University of Oxford, 16-18 September 1981. Abstracts.英国药理学会五十周年会议论文集，牛津大学，1981年9月16 - 18日。摘要
Br J Pharmacol. 1981 Dec;74(4):757P-988P.
7
The influence of digoxin antibodies on digoxin disposition and effect: studies in guinea-pigs and HeLa cells.地高辛抗体对地高辛处置及效应的影响：豚鼠和人宫颈癌细胞系（HeLa细胞）研究
Br J Pharmacol. 1985 Jan;84(1):157-63.
8
Functional capacity of immunoglobulin G preparations and the F(ab')2 split product.免疫球蛋白G制剂及F(ab')2裂解产物的功能活性
J Clin Microbiol. 1989 Apr;27(4):640-3. doi: 10.1128/jcm.27.4.640-643.1989.