Whittingham S, Morstyn G, Wilson J W, Vadas M A
Blood. 1981 Oct;58(4):768-71.
An autoantibody that reacted with nuclei of polymorphonuclear neutrophils (PMN) was detected at titers of greater than 10 in sera of 25 of 50 patients with rheumatoid arthritis and 36 of 50 with autoimmune chronic active hepatitis but in none of 160 controls comprising 24 patients with alcoholic cirrhosis, 36 with multiple myeloma, and 100 healthy subjects. Through the use of enriched populations of hemopoietic cells, this antibody was shown to be cell-specific, reacting only with the nucleus of the mature neutrophil. It was unreactive with nuclei of progenitor cells in the myeloid series and with nuclei of eosinophils, monocytes, lymphocytes, and thymocytes. It reacted with a determinant that appeared to be a differentiation antigen. This cell-specific autoantibody may prove to be of value in analytical studies of granulocyte maturation.
在50例类风湿性关节炎患者的25例血清以及50例自身免疫性慢性活动性肝炎患者的36例血清中，检测到一种与多形核中性粒细胞（PMN）细胞核发生反应的自身抗体，其滴度大于10，而在由24例酒精性肝硬化患者、36例多发性骨髓瘤患者和100名健康受试者组成的160名对照中均未检测到。通过使用富集的造血细胞群体，该抗体显示为细胞特异性，仅与成熟中性粒细胞的细胞核发生反应。它与髓系祖细胞的细胞核以及嗜酸性粒细胞、单核细胞、淋巴细胞和胸腺细胞的细胞核均无反应。它与一种似乎是分化抗原的决定簇发生反应。这种细胞特异性自身抗体可能在粒细胞成熟的分析研究中具有价值。
