Hurd E R, Andreis M, Ziff M
Clin Exp Immunol. 1977 Jun;28(3):413-25.
The possible role of phagocytosis of circulating immune complexes by neutrophils in the production of the neutropenia of Felty's syndrome has been investigated. Normal neutrophils phagocytosed massive inclusions from the sera from twelve of fifteen patients with Felty's syndrome when incubated with these sera. Such inclusions were phagocytosed from only three of fifteen patients with seropositive RA who did not have Felty's syndrome. Normal neutrophils were more effective than patient neutrophils with regard to phagocytosis of inclusions from the patients' serum suggesting a defect in phagocytic function of Felty's neutrophils. The titre of granulocyte-reactive antinuclear antibodies did not appear to be related to the degree of neutropenia. The data suggest that phagocytosis of circulating immune complexes by neutrophils may interfere with the function of these cells in combating infection and also render them susceptible to removal from the circulation thus leading to the development of neutropenia.
已经对中性粒细胞吞噬循环免疫复合物在费尔蒂综合征中性粒细胞减少症产生中的可能作用进行了研究。正常中性粒细胞与15例费尔蒂综合征患者中12例患者的血清一起孵育时，会吞噬大量来自这些血清的内含物。而在15例血清阳性但无费尔蒂综合征的类风湿关节炎患者中，只有3例患者的血清中的此类内含物会被吞噬。就吞噬患者血清中的内含物而言，正常中性粒细胞比患者自身的中性粒细胞更有效，这表明费尔蒂综合征患者的中性粒细胞吞噬功能存在缺陷。粒细胞反应性抗核抗体的滴度似乎与中性粒细胞减少的程度无关。数据表明，中性粒细胞对循环免疫复合物的吞噬可能会干扰这些细胞对抗感染的功能，还会使它们易于从循环中清除，从而导致中性粒细胞减少症的发生。
