Tambic T, Kropec I, Kosuta D
Clin Ther. 1981;4(1):43-7.
The efficacy and tolerance of netilmicin administered in a simplified dosage schedule (150 mg BID) were evaluated in an open study of 20 patients with acute systemic infections. Duration of therapy ranged from 6 to 11 days. All isolated causative organisms were eradicated; 85% (17/20) of the patients experienced complete clinical resolution, and the remaining 15% (3/20) experienced definite improvement. No patients developed nephrotoxicity of ototoxicity. The results of this study demonstrate that netilmicin is both effective in the treatment of serious systemic infections and well tolerated when administered at 150 mg twice daily.
在一项针对20例急性全身感染患者的开放性研究中，评估了采用简化给药方案（150毫克，每日两次）给予奈替米星的疗效和耐受性。治疗持续时间为6至11天。所有分离出的致病微生物均被根除；85%（17/20）的患者实现了完全临床缓解，其余15%（3/20）的患者有明显改善。没有患者出现肾毒性或耳毒性。这项研究的结果表明，奈替米星在治疗严重全身感染方面有效，并且每日两次给予150毫克时耐受性良好。
