Andreoni M, Andreoni S, Franchino L, Ricciardiello P T, Fortina A
Divisione di Medicina Infettivi, Ospedale Maggiore della Carità, Novara.
Minerva Med. 1990 Oct;81(10):707-12.
The Authors report the results obtained in 35 patients of either sex suffering from various systemic infections and treated with netilmicin. Netilmicin has been intramuscularly administered in once daily dose of 4.5 mg/kg (mean daily dose 294.3 mg) for a mean duration of 17.8 days. The clinical resolution of the infections has been achieved in 97.1% (34 patients) of the study population; only one patient showed failure. Thirty-three of the 35 baseline causative pathogens have been eradicated. The local and systemic tolerability was good. The serum pharmacokinetics showed bactericidal levels of netilmicin and no serum accumulation.
作者报告了35例患有各种全身感染并接受奈替米星治疗的不同性别的患者所获得的结果。奈替米星采用每日一次肌肉注射给药，剂量为4.5mg/kg（平均每日剂量294.3mg），平均疗程为17.8天。97.1%（34例患者）的研究人群实现了感染的临床治愈；仅1例患者治疗失败。35种基线致病病原体中的33种已被根除。局部和全身耐受性良好。血清药代动力学显示奈替米星达到杀菌水平且无血清蓄积。
