Friesen W T, Hekster Y A, Vree T B
Drug Intell Clin Pharm. 1981 May;15(5):325-30. doi: 10.1177/106002808101500502.
The recent marketing of trimethoprim (TMP) as a single drug has resulted in interest in the use of this drug to treat common infections. The history and antibacterial properties of TMP are reviewed. Indications for the clinical use of TMP are presented, and possible new uses for the drug are considered. The significance of adverse effects is discussed. The pharmacokinetic properties of TMP are reviewed with particular emphasis on the renal handling of the drug and its advantages over TMP/sulfonamide combinations in relation to renal function and toxicity.
甲氧苄啶（TMP）作为单一药物近期上市，引发了人们对使用该药治疗常见感染的兴趣。本文综述了TMP的历史及抗菌特性。介绍了TMP临床应用的适应证，并探讨了该药可能的新用途。讨论了不良反应的重要性。对TMP的药代动力学特性进行了综述，特别强调了该药的肾脏处理过程，以及与TMP/磺胺类药物联合制剂相比，在肾功能和毒性方面的优势。
