Haase A T, Swoveland P, Stowring L, Ventura P, Johnson K P, Norrby E, Gibbs C J
J Infect Dis. 1981 Aug;144(2):154-60. doi: 10.1093/infdis/144.2.154.
The measles virus genome was traced in acute and chronic infections of the central nervous system in hamsters and humans. The extent of viral replication and gene expression was assessed by the techniques of in situ hybridization and immunofluorescence. Both replication and gene expression were restricted in chronically infected hamsters and in humans with subacute sclerosing panencephalitis. It is proposed that restriction plays an important role in persistence of measles virus and the slow evolution of disease in these and other slow infections.
在仓鼠和人类中枢神经系统的急性和慢性感染中追踪到了麻疹病毒基因组。通过原位杂交和免疫荧光技术评估了病毒复制和基因表达的程度。在慢性感染的仓鼠和患有亚急性硬化性全脑炎的人类中，病毒复制和基因表达均受到限制。有人提出，这种限制在麻疹病毒的持续存在以及这些和其他慢感染疾病的缓慢演变中起着重要作用。
