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亚急性硬化性全脑炎患者大脑中一种异常的核内结构(?病毒核衣壳)。

An unusual intranuclear structure (? viral nucleocapsid) in the brain in subacute sclerosing panencephalitis.

作者信息

Dayan A D, Majumdar S, Hughes W, Heathfield K W

出版信息

J Neurol Neurosurg Psychiatry. 1974 Feb;37(2):201-6. doi: 10.1136/jnnp.37.2.201.

Abstract

A brain biopsy was examined from a 7 year old boy with subacute sclerosing panencephalitis. Intranuclear deposits of measles antigens were demonstrated in parenchymal cells by immunofluorescence. Electron microscopy showed viral nucleocapsids in nucleoliform inclusions and unusual rod-like intranuclear structures which resemble structures previously described only in tissue cultures infected with measles virus.

摘要

对一名患有亚急性硬化性全脑炎的7岁男孩进行了脑活检。通过免疫荧光法在实质细胞中证实了麻疹抗原的核内沉积。电子显微镜检查显示核仁样包涵体中有病毒核衣壳以及不寻常的杆状核内结构,这些结构类似于之前仅在感染麻疹病毒的组织培养物中描述过的结构。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef2a/494612/06cbdfbdb15d/jnnpsyc00188-0081-a.jpg

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