Saito A
Nihon Sanka Fujinka Gakkai Zasshi. 1981 Aug;33(8):1227-34.
The 4 day cycling Wistar strain rats were sacrificed by decapitation on the several conditions. By radioimmunoassay, hypothalamic luteinizing hormone-releasing hormone (LH-RH) and serum luteinizing hormone (LH) were measured. From the present experiments, the following results were obtained. 1. At 17:00 on proestrus, a peak in serum LH level was observed. At the same time, hypothalamic LH-RH content was decreased. 2. After the administration of estradiol (E2) on diestrus I, hypothalamic LH-RH content increased gradually and reached the peak about one day later. Moreover, serum LH peak appeared on diestrus II. But the change of E2 administration time didn't take part in the time of LH peak. 3. When the group of the rats were administered progesterone at appropriated time in addition to the E2 administration at 12:00 on diestrus I, serum LH peak on diestrus II was repressed through the changes of LH-RH.
将4日龄的Wistar品系大鼠在几种条件下断头处死。通过放射免疫分析法测定下丘脑促黄体生成激素释放激素（LH-RH）和血清促黄体生成激素（LH）。从目前的实验中，得到了以下结果。1. 在动情前期的17:00，观察到血清LH水平出现峰值。与此同时，下丘脑LH-RH含量降低。2. 在动情间期I给予雌二醇（E2）后，下丘脑LH-RH含量逐渐增加，约一天后达到峰值。此外，血清LH峰值出现在动情间期II。但是E2给药时间的改变并不影响LH峰值出现的时间。3. 当在动情间期I的12:00给予E2的同时，在适当时间给大鼠组给予孕酮时，动情间期II的血清LH峰值通过LH-RH的变化受到抑制。
